diff --git a/freqtrade/configuration/config_validation.py b/freqtrade/configuration/config_validation.py
index 4bfd24677..ca0e01ba0 100644
--- a/freqtrade/configuration/config_validation.py
+++ b/freqtrade/configuration/config_validation.py
@@ -131,3 +131,10 @@ def _validate_whitelist(conf: Dict[str, Any]) -> None:
         if (pl.get('method') == 'StaticPairList'
                 and not conf.get('exchange', {}).get('pair_whitelist')):
             raise OperationalException("StaticPairList requires pair_whitelist to be set.")
+
+        if pl.get('method') == 'StaticPairList':
+            stake = conf['stake_currency']
+            pairlist = conf['exchange'].get('pair_whitelist')
+            if not all([p.endswith(f'/{stake}') for p in pairlist]):
+                raise OperationalException(
+                    f"Stake-currency {stake} not compatible with pair-whitelist.")
diff --git a/tests/test_configuration.py b/tests/test_configuration.py
index ae85c7493..7f708934b 100644
--- a/tests/test_configuration.py
+++ b/tests/test_configuration.py
@@ -798,6 +798,12 @@ def test_validate_whitelist(default_conf):
 
     validate_config_consistency(conf)
 
+    conf = deepcopy(default_conf)
+    conf['stake_currency'] = 'USDT'
+    with pytest.raises(OperationalException,
+                       match="Stake-currency USDT not compatible with pair-whitelist."):
+        validate_config_consistency(conf)
+
 
 def test_load_config_test_comments() -> None:
     """