diff --git a/freqtrade/exchange/__init__.py b/freqtrade/exchange/__init__.py
index 7fd0e5f43..4af9db6db 100644
--- a/freqtrade/exchange/__init__.py
+++ b/freqtrade/exchange/__init__.py
@@ -375,6 +375,8 @@ class Exchange(object):
     def get_ticker(self, pair: str, refresh: Optional[bool] = True) -> dict:
         if refresh or pair not in self._cached_ticker.keys():
             try:
+                if pair not in self._api.markets:
+                    raise DependencyException(f"Pair {pair} not available")
                 data = self._api.fetch_ticker(pair)
                 try:
                     self._cached_ticker[pair] = {
diff --git a/freqtrade/rpc/rpc.py b/freqtrade/rpc/rpc.py
index d653ea176..900ad1998 100644
--- a/freqtrade/rpc/rpc.py
+++ b/freqtrade/rpc/rpc.py
@@ -10,10 +10,10 @@ from typing import Dict, Any, List, Optional
 
 import arrow
 import sqlalchemy as sql
-from numpy import mean, nan_to_num
+from numpy import mean, nan_to_num, NAN
 from pandas import DataFrame
 
-from freqtrade import TemporaryError
+from freqtrade import TemporaryError, DependencyException
 from freqtrade.fiat_convert import CryptoToFiatConverter
 from freqtrade.misc import shorten_date
 from freqtrade.persistence import Trade
@@ -93,7 +93,10 @@ class RPC(object):
                 if trade.open_order_id:
                     order = self._freqtrade.exchange.get_order(trade.open_order_id, trade.pair)
                 # calculate profit and send message to user
-                current_rate = self._freqtrade.exchange.get_ticker(trade.pair, False)['bid']
+                try:
+                    current_rate = self._freqtrade.exchange.get_ticker(trade.pair, False)['bid']
+                except DependencyException:
+                    current_rate = NAN
                 current_profit = trade.calc_profit_percent(current_rate)
                 fmt_close_profit = (f'{round(trade.close_profit * 100, 2):.2f}%'
                                     if trade.close_profit else None)
@@ -122,7 +125,10 @@ class RPC(object):
             trades_list = []
             for trade in trades:
                 # calculate profit and send message to user
-                current_rate = self._freqtrade.exchange.get_ticker(trade.pair, False)['bid']
+                try:
+                    current_rate = self._freqtrade.exchange.get_ticker(trade.pair, False)['bid']
+                except DependencyException:
+                    current_rate = NAN
                 trade_perc = (100 * trade.calc_profit_percent(current_rate))
                 trades_list.append([
                     trade.id,
@@ -207,7 +213,10 @@ class RPC(object):
                 profit_closed_percent.append(profit_percent)
             else:
                 # Get current rate
-                current_rate = self._freqtrade.exchange.get_ticker(trade.pair, False)['bid']
+                try:
+                    current_rate = self._freqtrade.exchange.get_ticker(trade.pair, False)['bid']
+                except DependencyException:
+                    current_rate = NAN
                 profit_percent = trade.calc_profit_percent(rate=current_rate)
 
             profit_all_coin.append(
@@ -275,7 +284,7 @@ class RPC(object):
                         rate = 1.0 / self._freqtrade.exchange.get_ticker('BTC/USDT', False)['bid']
                     else:
                         rate = self._freqtrade.exchange.get_ticker(coin + '/BTC', False)['bid']
-                except TemporaryError:
+                except (TemporaryError, DependencyException):
                     continue
             est_btc: float = rate * balance['total']
             total = total + est_btc
diff --git a/freqtrade/tests/exchange/test_exchange.py b/freqtrade/tests/exchange/test_exchange.py
index 93cd1e546..788ef4518 100644
--- a/freqtrade/tests/exchange/test_exchange.py
+++ b/freqtrade/tests/exchange/test_exchange.py
@@ -572,6 +572,7 @@ def test_get_ticker(default_conf, mocker):
         'last': 0.0001,
     }
     api_mock.fetch_ticker = MagicMock(return_value=tick)
+    api_mock.markets = {'ETH/BTC': {}}
     exchange = get_patched_exchange(mocker, default_conf, api_mock)
     # retrieve original ticker
     ticker = exchange.get_ticker(pair='ETH/BTC')
@@ -614,6 +615,9 @@ def test_get_ticker(default_conf, mocker):
     exchange = get_patched_exchange(mocker, default_conf, api_mock)
     exchange.get_ticker(pair='ETH/BTC', refresh=True)
 
+    with pytest.raises(DependencyException, match=r'Pair XRP/ETH not available'):
+        exchange.get_ticker(pair='XRP/ETH', refresh=True)
+
 
 def test_get_history(default_conf, mocker, caplog):
     exchange = get_patched_exchange(mocker, default_conf)