diff --git a/freqtrade/rpc/rpc.py b/freqtrade/rpc/rpc.py
index 42ab76622..70a99a186 100644
--- a/freqtrade/rpc/rpc.py
+++ b/freqtrade/rpc/rpc.py
@@ -20,6 +20,7 @@ from freqtrade.exchange import timeframe_to_minutes, timeframe_to_msecs
 from freqtrade.loggers import bufferHandler
 from freqtrade.misc import shorten_date
 from freqtrade.persistence import PairLocks, Trade
+from freqtrade.plugins.pairlist.pairlist_helpers import expand_pairlist
 from freqtrade.rpc.fiat_convert import CryptoToFiatConverter
 from freqtrade.state import State
 from freqtrade.strategy.interface import SellType
@@ -673,23 +674,23 @@ class RPC:
         """ Returns the currently active blacklist"""
         errors = {}
         if add:
-            stake_currency = self._freqtrade.config.get('stake_currency')
             for pair in add:
-                if self._freqtrade.exchange.get_pair_quote_currency(pair) == stake_currency:
-                    if pair not in self._freqtrade.pairlists.blacklist:
+                if pair not in self._freqtrade.pairlists.blacklist:
+                    try:
+                        expand_pairlist([pair], self._freqtrade.exchange.get_markets().keys())
                         self._freqtrade.pairlists.blacklist.append(pair)
-                    else:
-                        errors[pair] = {
-                            'error_msg': f'Pair {pair} already in pairlist.'}
 
+                    except ValueError:
+                        errors[pair] = {
+                            'error_msg': f'Pair {pair} is not a valid wildcard.'}
                 else:
                     errors[pair] = {
-                        'error_msg': f"Pair {pair} does not match stake currency."
-                    }
+                        'error_msg': f'Pair {pair} already in pairlist.'}
 
         res = {'method': self._freqtrade.pairlists.name_list,
                'length': len(self._freqtrade.pairlists.blacklist),
                'blacklist': self._freqtrade.pairlists.blacklist,
+               'blacklist_expanded': self._freqtrade.pairlists.expanded_blacklist,
                'errors': errors,
                }
         return res
diff --git a/tests/rpc/test_rpc.py b/tests/rpc/test_rpc.py
index 19788c067..8ec356d54 100644
--- a/tests/rpc/test_rpc.py
+++ b/tests/rpc/test_rpc.py
@@ -957,14 +957,24 @@ def test_rpc_blacklist(mocker, default_conf) -> None:
     assert isinstance(ret['errors'], dict)
     assert ret['errors']['ETH/BTC']['error_msg'] == 'Pair ETH/BTC already in pairlist.'
 
-    ret = rpc._rpc_blacklist(["ETH/ETH"])
+    ret = rpc._rpc_blacklist(["*/BTC"])
     assert 'StaticPairList' in ret['method']
     assert len(ret['blacklist']) == 3
     assert ret['blacklist'] == default_conf['exchange']['pair_blacklist']
     assert ret['blacklist'] == ['DOGE/BTC', 'HOT/BTC', 'ETH/BTC']
+    assert ret['blacklist_expanded'] == ['ETH/BTC']
+    assert 'errors' in ret
+    assert isinstance(ret['errors'], dict)
+    assert ret['errors'] == {'*/BTC': {'error_msg': 'Pair */BTC is not a valid wildcard.'}}
+
+    ret = rpc._rpc_blacklist(["XRP/.*"])
+    assert 'StaticPairList' in ret['method']
+    assert len(ret['blacklist']) == 4
+    assert ret['blacklist'] == default_conf['exchange']['pair_blacklist']
+    assert ret['blacklist'] == ['DOGE/BTC', 'HOT/BTC', 'ETH/BTC', 'XRP/.*']
+    assert ret['blacklist_expanded'] == ['ETH/BTC', 'XRP/BTC']
     assert 'errors' in ret
     assert isinstance(ret['errors'], dict)
-    assert ret['errors']['ETH/ETH']['error_msg'] == 'Pair ETH/ETH does not match stake currency.'
 
 
 def test_rpc_edge_disabled(mocker, default_conf) -> None:
diff --git a/tests/rpc/test_rpc_apiserver.py b/tests/rpc/test_rpc_apiserver.py
index 5e608fb25..8da4ebfe7 100644
--- a/tests/rpc/test_rpc_apiserver.py
+++ b/tests/rpc/test_rpc_apiserver.py
@@ -730,7 +730,9 @@ def test_api_blacklist(botclient, mocker):
 
     rc = client_get(client, f"{BASE_URI}/blacklist")
     assert_response(rc)
+    # DOGE and HOT are not in the markets mock!
     assert rc.json == {"blacklist": ["DOGE/BTC", "HOT/BTC"],
+                       "blacklist_expanded": [],
                        "length": 2,
                        "method": ["StaticPairList"],
                        "errors": {},
@@ -741,11 +743,22 @@ def test_api_blacklist(botclient, mocker):
                      data='{"blacklist": ["ETH/BTC"]}')
     assert_response(rc)
     assert rc.json == {"blacklist": ["DOGE/BTC", "HOT/BTC", "ETH/BTC"],
+                       "blacklist_expanded": ["ETH/BTC"],
                        "length": 3,
                        "method": ["StaticPairList"],
                        "errors": {},
                        }
 
+    rc = client_post(client, f"{BASE_URI}/blacklist",
+                     data='{"blacklist": ["XRP/.*"]}')
+    assert_response(rc)
+    assert rc.json == {"blacklist": ["DOGE/BTC", "HOT/BTC", "ETH/BTC", "XRP/.*"],
+                       "blacklist_expanded": ["ETH/BTC", "XRP/BTC"],
+                       "length": 4,
+                       "method": ["StaticPairList"],
+                       "errors": {},
+                       }
+
 
 def test_api_whitelist(botclient):
     ftbot, client = botclient
diff --git a/tests/rpc/test_rpc_telegram.py b/tests/rpc/test_rpc_telegram.py
index 97b9e5e7c..a21a19e3a 100644
--- a/tests/rpc/test_rpc_telegram.py
+++ b/tests/rpc/test_rpc_telegram.py
@@ -1011,15 +1011,13 @@ def test_blacklist_static(default_conf, update, mocker) -> None:
 
     msg_mock.reset_mock()
     context = MagicMock()
-    context.args = ["ETH/ETH"]
+    context.args = ["XRP/.*"]
     telegram._blacklist(update=update, context=context)
-    assert msg_mock.call_count == 2
-    assert ("Error adding `ETH/ETH` to blacklist: `Pair ETH/ETH does not match stake currency.`"
-            in msg_mock.call_args_list[0][0][0])
+    assert msg_mock.call_count == 1
 
-    assert ("Blacklist contains 3 pairs\n`DOGE/BTC, HOT/BTC, ETH/BTC`"
-            in msg_mock.call_args_list[1][0][0])
-    assert freqtradebot.pairlists.blacklist == ["DOGE/BTC", "HOT/BTC", "ETH/BTC"]
+    assert ("Blacklist contains 4 pairs\n`DOGE/BTC, HOT/BTC, ETH/BTC, XRP/.*`"
+            in msg_mock.call_args_list[0][0][0])
+    assert freqtradebot.pairlists.blacklist == ["DOGE/BTC", "HOT/BTC", "ETH/BTC", "XRP/.*"]
 
 
 def test_telegram_logs(default_conf, update, mocker) -> None: