diff --git a/freqtrade/freqtradebot.py b/freqtrade/freqtradebot.py
index 425b7e3a9..7d5cddd6c 100644
--- a/freqtrade/freqtradebot.py
+++ b/freqtrade/freqtradebot.py
@@ -96,6 +96,8 @@ class FreqtradeBot(object):
         : return: None
         """
         self.rpc.startup_messages(self.config, self.pairlists)
+        # Adjust stoploss if it was changed
+        Trade.stoploss_reinitialization(self.strategy.stoploss)
 
     def process(self) -> bool:
         """
diff --git a/freqtrade/persistence.py b/freqtrade/persistence.py
index e64e0b89c..3fc9a189e 100644
--- a/freqtrade/persistence.py
+++ b/freqtrade/persistence.py
@@ -421,3 +421,23 @@ class Trade(_DECL_BASE):
         Query trades from persistence layer
         """
         return Trade.query.filter(Trade.is_open.is_(True)).all()
+
+    @staticmethod
+    def stoploss_reinitialization(desired_stoploss):
+        """
+        Adjust initial Stoploss to desired stoploss for all open trades.
+        """
+        for trade in Trade.get_open_trades():
+            logger.info("Found open trade: %s", trade)
+
+            # skip case if trailing-stop changed the stoploss already.
+            if (trade.stop_loss == trade.initial_stop_loss
+               and trade.initial_stop_loss_pct != desired_stoploss):
+                # Stoploss value got changed
+
+                logger.info(f"Stoploss for {trade} needs adjustment.")
+                logger.info(f"Stoploss: {trade.initial_stop_loss_pct}: {desired_stoploss}")
+                # Force reset of stoploss
+                trade.stop_loss = None
+                trade.adjust_stop_loss(trade.open_rate, desired_stoploss)
+                logger.info(f"new stoploss: {trade.stop_loss}, ")
diff --git a/freqtrade/tests/test_freqtradebot.py b/freqtrade/tests/test_freqtradebot.py
index 67b05ac3e..c683f6273 100644
--- a/freqtrade/tests/test_freqtradebot.py
+++ b/freqtrade/tests/test_freqtradebot.py
@@ -114,6 +114,7 @@ def test_cleanup(mocker, default_conf, caplog) -> None:
 def test_worker_running(mocker, default_conf, caplog) -> None:
     mock_throttle = MagicMock()
     mocker.patch('freqtrade.worker.Worker._throttle', mock_throttle)
+    mocker.patch('freqtrade.persistence.Trade.adjust_initial_stoploss', MagicMock())
 
     worker = get_patched_worker(mocker, default_conf)