diff --git a/freqtrade/configuration/config_validation.py b/freqtrade/configuration/config_validation.py
index 92846b704..6a8374e6d 100644
--- a/freqtrade/configuration/config_validation.py
+++ b/freqtrade/configuration/config_validation.py
@@ -68,6 +68,10 @@ def validate_config_consistency(conf: Dict[str, Any]) -> None:
 
 def _validate_trailing_stoploss(conf: Dict[str, Any]) -> None:
 
+    if conf.get('stoploss') == 0.0:
+        raise OperationalException(
+            'The config stoploss needs to be different from 0 to avoid problems with sell orders.'
+            )
     # Skip if trailing stoploss is not activated
     if not conf.get('trailing_stop', False):
         return
@@ -79,12 +83,19 @@ def _validate_trailing_stoploss(conf: Dict[str, Any]) -> None:
     if tsl_only_offset:
         if tsl_positive == 0.0:
             raise OperationalException(
-                f'The config trailing_only_offset_is_reached needs '
+                'The config trailing_only_offset_is_reached needs '
                 'trailing_stop_positive_offset to be more than 0 in your config.')
     if tsl_positive > 0 and 0 < tsl_offset <= tsl_positive:
         raise OperationalException(
-            f'The config trailing_stop_positive_offset needs '
-            'to be greater than trailing_stop_positive_offset in your config.')
+            'The config trailing_stop_positive_offset needs '
+            'to be greater than trailing_stop_positive in your config.')
+
+    # Fetch again without default
+    if 'trailing_stop_positive' in conf and float(conf['trailing_stop_positive']) == 0.0:
+        raise OperationalException(
+            'The config trailing_stop_positive needs to be different from 0 '
+            'to avoid problems with sell orders.'
+        )
 
 
 def _validate_edge(conf: Dict[str, Any]) -> None:
diff --git a/freqtrade/tests/test_configuration.py b/freqtrade/tests/test_configuration.py
index a2a87c2cf..10ce7e8cf 100644
--- a/freqtrade/tests/test_configuration.py
+++ b/freqtrade/tests/test_configuration.py
@@ -648,6 +648,12 @@ def test_create_userdata_dir_exists_exception(mocker, default_conf, caplog) -> N
 
 
 def test_validate_tsl(default_conf):
+    default_conf['stoploss'] = 0.0
+    with pytest.raises(OperationalException, match='The config stoploss needs to be different '
+                                                   'from 0 to avoid problems with sell orders.'):
+        validate_config_consistency(default_conf)
+    default_conf['stoploss'] = -0.10
+
     default_conf['trailing_stop'] = True
     default_conf['trailing_stop_positive'] = 0
     default_conf['trailing_stop_positive_offset'] = 0
@@ -662,13 +668,22 @@ def test_validate_tsl(default_conf):
     default_conf['trailing_stop_positive'] = 0.015
     with pytest.raises(OperationalException,
                        match=r'The config trailing_stop_positive_offset needs '
-                       'to be greater than trailing_stop_positive_offset in your config.'):
+                       'to be greater than trailing_stop_positive in your config.'):
         validate_config_consistency(default_conf)
 
     default_conf['trailing_stop_positive'] = 0.01
     default_conf['trailing_stop_positive_offset'] = 0.015
     validate_config_consistency(default_conf)
 
+    # 0 trailing stop positive - results in "Order would trigger immediately"
+    default_conf['trailing_stop_positive'] = 0
+    default_conf['trailing_stop_positive_offset'] = 0.02
+    default_conf['trailing_only_offset_is_reached'] = False
+    with pytest.raises(OperationalException,
+                       match='The config trailing_stop_positive needs to be different from 0 '
+                       'to avoid problems with sell orders'):
+        validate_config_consistency(default_conf)
+
 
 def test_validate_edge(edge_conf):
     edge_conf.update({"pairlist": {