diff --git a/freqtrade/edge/edge_positioning.py b/freqtrade/edge/edge_positioning.py
index d1f76c21f..334aabfab 100644
--- a/freqtrade/edge/edge_positioning.py
+++ b/freqtrade/edge/edge_positioning.py
@@ -81,10 +81,15 @@ class Edge:
         if config.get('fee'):
             self.fee = config['fee']
         else:
-            self.fee = self.exchange.get_fee(symbol=expand_pairlist(
-                self.config['exchange']['pair_whitelist'], list(self.exchange.markets))[0])
+            try:
+                self.fee = self.exchange.get_fee(symbol=expand_pairlist(
+                    self.config['exchange']['pair_whitelist'], list(self.exchange.markets))[0])
+            except IndexError:
+                self.fee = None
 
     def calculate(self, pairs: List[str]) -> bool:
+        if self.fee is None and pairs:
+            self.fee = self.exchange.get_fee(pairs[0])
 
         heartbeat = self.edge_config.get('process_throttle_secs')
 
diff --git a/tests/edge/test_edge.py b/tests/edge/test_edge.py
index 5142dd985..25e0da5e2 100644
--- a/tests/edge/test_edge.py
+++ b/tests/edge/test_edge.py
@@ -330,11 +330,11 @@ def test_edge_process_no_data(mocker, edge_conf, caplog):
 
 def test_edge_process_no_trades(mocker, edge_conf, caplog):
     freqtrade = get_patched_freqtradebot(mocker, edge_conf)
-    mocker.patch('freqtrade.exchange.Exchange.get_fee', MagicMock(return_value=0.001))
-    mocker.patch('freqtrade.edge.edge_positioning.refresh_data', MagicMock())
+    mocker.patch('freqtrade.exchange.Exchange.get_fee', return_value=0.001)
+    mocker.patch('freqtrade.edge.edge_positioning.refresh_data', )
     mocker.patch('freqtrade.edge.edge_positioning.load_data', mocked_load_data)
     # Return empty
-    mocker.patch('freqtrade.edge.Edge._find_trades_for_stoploss_range', MagicMock(return_value=[]))
+    mocker.patch('freqtrade.edge.Edge._find_trades_for_stoploss_range', return_value=[])
     edge = Edge(edge_conf, freqtrade.exchange, freqtrade.strategy)
 
     assert not edge.calculate(edge_conf['exchange']['pair_whitelist'])
@@ -342,6 +342,23 @@ def test_edge_process_no_trades(mocker, edge_conf, caplog):
     assert log_has("No trades found.", caplog)
 
 
+def test_edge_process_no_pairs(mocker, edge_conf, caplog):
+    edge_conf['exchange']['pair_whitelist'] = []
+    freqtrade = get_patched_freqtradebot(mocker, edge_conf)
+    fee_mock = mocker.patch('freqtrade.exchange.Exchange.get_fee', return_value=0.001)
+    mocker.patch('freqtrade.edge.edge_positioning.refresh_data')
+    mocker.patch('freqtrade.edge.edge_positioning.load_data', mocked_load_data)
+    # Return empty
+    mocker.patch('freqtrade.edge.Edge._find_trades_for_stoploss_range', return_value=[])
+    edge = Edge(edge_conf, freqtrade.exchange, freqtrade.strategy)
+    assert fee_mock.call_count == 0
+    assert edge.fee is None
+
+    assert not edge.calculate(['XRP/USDT'])
+    assert fee_mock.call_count == 1
+    assert edge.fee == 0.001
+
+
 def test_edge_init_error(mocker, edge_conf,):
     edge_conf['stake_amount'] = 0.5
     mocker.patch('freqtrade.exchange.Exchange.get_fee', MagicMock(return_value=0.001))