diff --git a/freqtrade/rpc/rpc.py b/freqtrade/rpc/rpc.py
index 37b246b1a..789d962f8 100644
--- a/freqtrade/rpc/rpc.py
+++ b/freqtrade/rpc/rpc.py
@@ -12,7 +12,7 @@ import psutil
 from dateutil.relativedelta import relativedelta
 from dateutil.tz import tzlocal
 from numpy import NAN, inf, int64, mean
-from pandas import DataFrame
+from pandas import DataFrame, NaT
 
 from freqtrade import __version__
 from freqtrade.configuration.timerange import TimeRange
@@ -963,8 +963,18 @@ class RPC:
                 sell_mask = (dataframe['sell'] == 1)
                 sell_signals = int(sell_mask.sum())
                 dataframe.loc[sell_mask, '_sell_signal_close'] = dataframe.loc[sell_mask, 'close']
-            dataframe = dataframe.replace([inf, -inf], NAN)
-            dataframe = dataframe.replace({NAN: None})
+
+            # band-aid until this is fixed:
+            # https://github.com/pandas-dev/pandas/issues/45836
+            datetime_types = ['datetime', 'datetime64', 'datetime64[ns, UTC]']
+            date_columns = dataframe.select_dtypes(include=datetime_types)
+            for date_column in date_columns:
+                # replace NaT with empty string,
+                # because if replaced with `None`
+                # it will be casted into NaT again
+                dataframe[date_column] = dataframe[date_column].astype(object).replace({NaT: None})
+
+            dataframe = dataframe.replace({inf: None, -inf: None, NAN: None})
 
         res = {
             'pair': pair,
diff --git a/tests/rpc/test_rpc_apiserver.py b/tests/rpc/test_rpc_apiserver.py
index 1c33dd928..5b19e5e05 100644
--- a/tests/rpc/test_rpc_apiserver.py
+++ b/tests/rpc/test_rpc_apiserver.py
@@ -7,6 +7,7 @@ from datetime import datetime, timedelta, timezone
 from pathlib import Path
 from unittest.mock import ANY, MagicMock, PropertyMock
 
+import pandas as pd
 import pytest
 import uvicorn
 from fastapi import FastAPI
@@ -1181,6 +1182,24 @@ def test_api_pair_candles(botclient, ohlcv_history):
                  0.7039405, 8.885e-05, 0, 0, 1511686800000, None, None]
 
              ])
+    ohlcv_history['sell'] = ohlcv_history['sell'].astype('float64')
+    ohlcv_history.at[0, 'sell'] = float('inf')
+    ohlcv_history['date1'] = ohlcv_history['date']
+    ohlcv_history.at[0, 'date1'] = pd.NaT
+
+    ftbot.dataprovider._set_cached_df("XRP/BTC", timeframe, ohlcv_history)
+    rc = client_get(client,
+                    f"{BASE_URI}/pair_candles?limit={amount}&pair=XRP%2FBTC&timeframe={timeframe}")
+    assert_response(rc)
+    assert (rc.json()['data'] ==
+            [['2017-11-26 08:50:00', 8.794e-05, 8.948e-05, 8.794e-05, 8.88e-05, 0.0877869,
+              None, 0, None, None, 1511686200000, None, None],
+             ['2017-11-26 08:55:00', 8.88e-05, 8.942e-05, 8.88e-05,
+                 8.893e-05, 0.05874751, 8.886500000000001e-05, 1, 0.0, '2017-11-26 08:55:00',
+                 1511686500000, 8.893e-05, None],
+             ['2017-11-26 09:00:00', 8.891e-05, 8.893e-05, 8.875e-05, 8.877e-05,
+                 0.7039405, 8.885e-05, 0, 0.0, '2017-11-26 09:00:00', 1511686800000, None, None]
+             ])
 
 
 def test_api_pair_history(botclient, ohlcv_history):