diff --git a/freqtrade/rpc/api_server.py b/freqtrade/rpc/api_server.py
index 4bbc8a1dc..0ae0698cd 100644
--- a/freqtrade/rpc/api_server.py
+++ b/freqtrade/rpc/api_server.py
@@ -17,8 +17,9 @@ from werkzeug.serving import make_server
 
 from freqtrade.__init__ import __version__
 from freqtrade.constants import DATETIME_PRINT_FORMAT
-from freqtrade.rpc.rpc import RPC, RPCException
+from freqtrade.persistence import Trade
 from freqtrade.rpc.fiat_convert import CryptoToFiatConverter
+from freqtrade.rpc.rpc import RPC, RPCException
 
 logger = logging.getLogger(__name__)
 
@@ -70,6 +71,11 @@ def rpc_catch_errors(func: Callable[..., Any]):
     return func_wrapper
 
 
+def shutdown_session(exception=None):
+    # Remove scoped session
+    Trade.session.remove()
+
+
 class ApiServer(RPC):
     """
     This class runs api server and provides rpc.rpc functionality to it
@@ -104,6 +110,8 @@ class ApiServer(RPC):
         self.jwt = JWTManager(self.app)
         self.app.json_encoder = ArrowJSONEncoder
 
+        self.app.teardown_appcontext(shutdown_session)
+
         # Register application handling
         self.register_rest_rpc_urls()
 
diff --git a/tests/rpc/test_rpc_apiserver.py b/tests/rpc/test_rpc_apiserver.py
index d9f5bf781..f8256f1ba 100644
--- a/tests/rpc/test_rpc_apiserver.py
+++ b/tests/rpc/test_rpc_apiserver.py
@@ -471,6 +471,7 @@ def test_api_edge_disabled(botclient, mocker, ticker, fee, markets):
     assert rc.json == {"error": "Error querying _edge: Edge is not enabled."}
 
 
+@pytest.mark.usefixtures("init_persistence")
 def test_api_profit(botclient, mocker, ticker, fee, markets, limit_buy_order, limit_sell_order):
     ftbot, client = botclient
     patch_get_signal(ftbot, (True, False))
@@ -498,6 +499,7 @@ def test_api_profit(botclient, mocker, ticker, fee, markets, limit_buy_order, li
     assert rc.json['best_pair'] == ''
     assert rc.json['best_rate'] == 0
 
+    trade = Trade.query.first()
     trade.update(limit_sell_order)
 
     trade.close_date = datetime.utcnow()