diff --git a/freqtrade/exchange/exchange.py b/freqtrade/exchange/exchange.py
index da89a7c8a..cfd12622b 100644
--- a/freqtrade/exchange/exchange.py
+++ b/freqtrade/exchange/exchange.py
@@ -9,7 +9,7 @@ import logging
 from copy import deepcopy
 from datetime import datetime, timedelta, timezone
 from math import ceil
-from typing import Any, Dict, List, Optional, Tuple
+from typing import Any, Coroutine, Dict, List, Optional, Tuple
 
 import arrow
 import ccxt
@@ -1371,6 +1371,22 @@ class Exchange:
         data = sorted(data, key=lambda x: x[0])
         return pair, timeframe, data
 
+    def _build_coroutine(self, pair: str, timeframe: str, since_ms: Optional[int]) -> Coroutine:
+        if not since_ms and self.required_candle_call_count > 1:
+            # Multiple calls for one pair - to get more history
+            one_call = timeframe_to_msecs(timeframe) * self.ohlcv_candle_limit(timeframe)
+            move_to = one_call * self.required_candle_call_count
+            now = timeframe_to_next_date(timeframe)
+            since_ms = int((now - timedelta(seconds=move_to // 1000)).timestamp() * 1000)
+
+        if since_ms:
+            return self._async_get_historic_ohlcv(
+                pair, timeframe, since_ms=since_ms, raise_=True)
+        else:
+            # One call ... "regular" refresh
+            return self._async_get_candle_history(
+                pair, timeframe, since_ms=since_ms)
+
     def refresh_latest_ohlcv(self, pair_list: ListPairsWithTimeframes, *,
                              since_ms: Optional[int] = None, cache: bool = True
                              ) -> Dict[Tuple[str, str], DataFrame]:
@@ -1389,22 +1405,15 @@ class Exchange:
         cached_pairs = []
         # Gather coroutines to run
         for pair, timeframe in set(pair_list):
+            if timeframe not in self.timeframes:
+                logger.warning(
+                    f"Cannot download ({pair}, {timeframe}) combination as this timeframe is "
+                    f"not available on {self.name}. Available timeframes are "
+                    f"{', '.join(self.timeframes)}.")
+                continue
             if ((pair, timeframe) not in self._klines or not cache
                     or self._now_is_time_to_refresh(pair, timeframe)):
-                if not since_ms and self.required_candle_call_count > 1:
-                    # Multiple calls for one pair - to get more history
-                    one_call = timeframe_to_msecs(timeframe) * self.ohlcv_candle_limit(timeframe)
-                    move_to = one_call * self.required_candle_call_count
-                    now = timeframe_to_next_date(timeframe)
-                    since_ms = int((now - timedelta(seconds=move_to // 1000)).timestamp() * 1000)
-
-                if since_ms:
-                    input_coroutines.append(self._async_get_historic_ohlcv(
-                        pair, timeframe, since_ms=since_ms, raise_=True))
-                else:
-                    # One call ... "regular" refresh
-                    input_coroutines.append(self._async_get_candle_history(
-                        pair, timeframe, since_ms=since_ms))
+                input_coroutines.append(self._build_coroutine(pair, timeframe, since_ms))
             else:
                 logger.debug(
                     "Using cached candle (OHLCV) data for pair %s, timeframe %s ...",
diff --git a/tests/conftest.py b/tests/conftest.py
index ae35b0326..57122c01c 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -107,6 +107,8 @@ def patch_exchange(mocker, api_mock=None, id='binance', mock_markets=True) -> No
         mocker.patch('freqtrade.exchange.Exchange._init_ccxt', MagicMock(return_value=api_mock))
     else:
         mocker.patch('freqtrade.exchange.Exchange._init_ccxt', MagicMock())
+        mocker.patch('freqtrade.exchange.Exchange.timeframes', PropertyMock(
+                return_value=['5m', '15m', '1h', '1d']))
 
 
 def get_patched_exchange(mocker, config, api_mock=None, id='binance',
diff --git a/tests/exchange/test_exchange.py b/tests/exchange/test_exchange.py
index 527e8050b..2bd84942d 100644
--- a/tests/exchange/test_exchange.py
+++ b/tests/exchange/test_exchange.py
@@ -1692,6 +1692,13 @@ def test_refresh_latest_ohlcv(mocker, default_conf, caplog) -> None:
                                         cache=False)
     assert len(res) == 3
     assert exchange._api_async.fetch_ohlcv.call_count == 3
+    exchange._api_async.fetch_ohlcv.reset_mock()
+    caplog.clear()
+    # Call with invalid timeframe
+    res = exchange.refresh_latest_ohlcv([('IOTA/ETH', '3m')],cache=False)
+    assert not res
+    assert len(res) == 0
+    assert log_has_re(r'Cannot download \(IOTA\/ETH, 3m\).*', caplog)
 
 
 @pytest.mark.asyncio